Biochemistry
Lifeng Meng; Ping Zhou; Weifeng Xu; Wei Bian; Yunxiao Lin; Ying Guan
Abstract
Gout is a complex and common form of arthritis which has brought great inconveniences to the normal lives of patients worldwide. However, the molecular basis of gouty arthritis is still incompletely understood, which has limited the identification of therapeutic targets. Here we show that the Smad ubiquitin ...
Read More
Gout is a complex and common form of arthritis which has brought great inconveniences to the normal lives of patients worldwide. However, the molecular basis of gouty arthritis is still incompletely understood, which has limited the identification of therapeutic targets. Here we show that the Smad ubiquitin regulatory factor 1 (Smurf1) is markedly lower in peripheral blood from human gouty arthritis patients. Smurf1 inhibitor A01 promoted mono-sodium urate (MSU) crystals-induced gouty arthritis. Mechanistic studies revealed that inhibition of Smurf1 promotes M1-like macrophage polarization through accelerating glycolysis, and the AMPK signaling pathway is involved in the regulatory role of Smurf1. In conclusion, Smurf1 acted as a suppressor in gouty arthritis, which might serve as a potential target for the therapies of gouty arthritis.
